Drug interactions
Paclitaxel + Teriflunomide
Severity: Moderate
Paclitaxel and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is metabolized by CYP2C8, which teriflunomide inhibits. Paclitaxel exposure may rise, increasing neutropenia and neuropathy. Additive myelosuppression is also possible.
What this interaction means in plain words
Paclitaxel and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Teriflunomide belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C8 by teriflunomide reduces paclitaxel clearance.
What to do
Monitor blood counts and neuropathy and reduce the paclitaxel dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Paclitaxel and Teriflunomide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Teriflunomide
Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Teriflunomide?
MediHelp rates the interaction as moderate. Paclitaxel and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel is metabolized by CYP2C8, which teriflunomide inhibits. Paclitaxel exposure may rise, increasing neutropenia and neuropathy. Additive myelosuppression is also possible.
How serious is the interaction between Paclitaxel and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy and reduce the paclitaxel dose if toxicity occurs.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
