Drug interactions
Paclitaxel + Tucatinib
Severity: Moderate
Paclitaxel and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may raise concentrations of CYP3A substrates such as paclitaxel. Higher exposure could worsen neutropenia and neuropathy.
What this interaction means in plain words
Paclitaxel and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing paclitaxel metabolism; paclitaxel is also cleared via CYP2C8.
What to do
Monitor blood counts and neuropathy and reduce the paclitaxel dose if toxicity develops. Avoid adding other CYP3A or CYP2C8 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Paclitaxel with Tucatinib?
MediHelp rates the interaction as moderate. Paclitaxel and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and may raise concentrations of CYP3A substrates such as paclitaxel. Higher exposure could worsen neutropenia and neuropathy.
How serious is the interaction between Paclitaxel and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy and reduce the paclitaxel dose if toxicity develops. Avoid adding other CYP3A or CYP2C8 inhibitors.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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