Drug interactions
Pacritinib + Prednisone
Severity: Minor
Pacritinib and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone is a weak CYP3A4 inducer and may modestly lower pacritinib exposure, which is CYP3A4-metabolized. The clinical significance is likely limited, though reduced efficacy is possible.
What this interaction means in plain words
Pacritinib and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pacritinib belongs to Oncology; Prednisone belongs to Endocrine.
Why it happens
Weak induction of CYP3A4 by prednisone may increase pacritinib metabolism.
What to do
Monitor spleen size and symptom response to pacritinib when prednisone is used long term. No empirical dose change is generally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Pacritinib with Prednisone?
MediHelp rates the interaction as minor. Pacritinib and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prednisone is a weak CYP3A4 inducer and may modestly lower pacritinib exposure, which is CYP3A4-metabolized. The clinical significance is likely limited, though reduced efficacy is possible.
How serious is the interaction between Pacritinib and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor spleen size and symptom response to pacritinib when prednisone is used long term. No empirical dose change is generally needed.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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