Drug interactions
Pacritinib + Sertraline
Severity: Moderate
Pacritinib and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is metabolised by CYP3A4, and inhibitors can raise exposure. It also prolongs the QT interval, which sertraline may modestly add to. Sertraline's CYP3A4 inhibition is weak.
What this interaction means in plain words
Pacritinib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pacritinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition raising pacritinib levels plus additive QT effects.
What to do
Monitor ECG and electrolytes and watch for bleeding and diarrhoea. Consider an alternative antidepressant if the QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Pacritinib with Sertraline?
MediHelp rates the interaction as moderate. Pacritinib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib is metabolised by CYP3A4, and inhibitors can raise exposure. It also prolongs the QT interval, which sertraline may modestly add to. Sertraline's CYP3A4 inhibition is weak.
How serious is the interaction between Pacritinib and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes and watch for bleeding and diarrhoea. Consider an alternative antidepressant if the QTc lengthens.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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