Drug interactions
Pacritinib + Topotecan
Severity: Moderate
Pacritinib and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib inhibits BCRP and may increase exposure to topotecan, a BCRP substrate. Both drugs can also cause cytopenias, compounding hematologic risk.
What this interaction means in plain words
Pacritinib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pacritinib belongs to Oncology; Topotecan belongs to Oncology.
Why it happens
Pacritinib inhibits BCRP efflux of topotecan, with additive myelosuppressive effects.
What to do
Monitor blood counts closely and consider topotecan dose reduction if cytopenias worsen. Avoid with oral topotecan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Pacritinib with Topotecan?
MediHelp rates the interaction as moderate. Pacritinib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib inhibits BCRP and may increase exposure to topotecan, a BCRP substrate. Both drugs can also cause cytopenias, compounding hematologic risk.
How serious is the interaction between Pacritinib and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and consider topotecan dose reduction if cytopenias worsen. Avoid with oral topotecan.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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