Drug interactions
Pacritinib + Verapamil
Severity: Major
Pacritinib and Verapamil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is metabolized mainly by CYP3A4, and verapamil is a moderate CYP3A4 inhibitor. Concurrent use can raise pacritinib exposure and increase the risk of adverse effects such as QT prolongation, bleeding and diarrhea.
What this interaction means in plain words
Pacritinib and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pacritinib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4-mediated metabolism of pacritinib, raising its plasma concentrations.
What to do
Avoid the combination where possible, and consider a non-interacting antihypertensive or antiarrhythmic. If it cannot be avoided, monitor ECG and QTc and watch for pacritinib toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Pacritinib with Verapamil?
MediHelp rates the interaction as major. Pacritinib and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pacritinib is metabolized mainly by CYP3A4, and verapamil is a moderate CYP3A4 inhibitor. Concurrent use can raise pacritinib exposure and increase the risk of adverse effects such as QT prolongation, bleeding and diarrhea.
How serious is the interaction between Pacritinib and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and consider a non-interacting antihypertensive or antiarrhythmic. If it cannot be avoided, monitor ECG and QTc and watch for pacritinib toxicity.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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