Drug interactions
Palbociclib + Ribociclib
Severity: Major
Palbociclib and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are CDK4/6 inhibitors with overlapping myelosuppression, and ribociclib may modestly raise palbociclib exposure through CYP3A4 inhibition. The combination is not an established regimen and adds toxicity without proven benefit.
What this interaction means in plain words
Palbociclib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Palbociclib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Duplicate CDK4/6 inhibition with additive neutropenia plus CYP3A4 inhibition by ribociclib.
What to do
Avoid concurrent use of the two CDK4/6 inhibitors. If a switch is made, follow each drug's labeling and monitor blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Palbociclib with Ribociclib?
MediHelp rates the interaction as major. Palbociclib and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are CDK4/6 inhibitors with overlapping myelosuppression, and ribociclib may modestly raise palbociclib exposure through CYP3A4 inhibition. The combination is not an established regimen and adds toxicity without proven benefit.
How serious is the interaction between Palbociclib and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of the two CDK4/6 inhibitors. If a switch is made, follow each drug's labeling and monitor blood counts.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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