Drug interactions
Palbociclib + Sirolimus
Severity: Moderate
Palbociclib and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is a weak CYP3A inhibitor and may increase sirolimus concentrations. Elevated sirolimus can worsen myelosuppression, hyperlipidemia, mouth ulcers and infection risk, which overlap with palbociclib neutropenia.
What this interaction means in plain words
Palbociclib and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palbociclib belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Palbociclib inhibits CYP3A4, reducing sirolimus metabolism.
What to do
Monitor sirolimus trough levels and blood counts when starting or stopping palbociclib. Reduce the sirolimus dose according to levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Palbociclib with Sirolimus?
MediHelp rates the interaction as moderate. Palbociclib and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib is a weak CYP3A inhibitor and may increase sirolimus concentrations. Elevated sirolimus can worsen myelosuppression, hyperlipidemia, mouth ulcers and infection risk, which overlap with palbociclib neutropenia.
How serious is the interaction between Palbociclib and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels and blood counts when starting or stopping palbociclib. Reduce the sirolimus dose according to levels.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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