Drug interactions
Palbociclib + Tacrolimus
Severity: Moderate
Palbociclib and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is a weak time-dependent CYP3A inhibitor and may raise concentrations of tacrolimus, a narrow therapeutic index CYP3A substrate. Increased tacrolimus exposure can lead to nephrotoxicity, neurotoxicity and tremor.
What this interaction means in plain words
Palbociclib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palbociclib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Palbociclib inhibits CYP3A4, reducing tacrolimus metabolism.
What to do
Monitor tacrolimus trough concentrations and renal function when starting or stopping palbociclib. Reduce tacrolimus dose as guided by levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Palbociclib with Tacrolimus?
MediHelp rates the interaction as moderate. Palbociclib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib is a weak time-dependent CYP3A inhibitor and may raise concentrations of tacrolimus, a narrow therapeutic index CYP3A substrate. Increased tacrolimus exposure can lead to nephrotoxicity, neurotoxicity and tremor.
How serious is the interaction between Palbociclib and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough concentrations and renal function when starting or stopping palbociclib. Reduce tacrolimus dose as guided by levels.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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