Drug interactions
Palbociclib + Tecovirimat
Severity: Minor
Palbociclib and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and might slightly lower palbociclib exposure. The clinical effect is likely small and tecovirimat is used for short courses.
What this interaction means in plain words
Palbociclib and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Palbociclib belongs to Oncology; Tecovirimat belongs to Miscellaneous.
Why it happens
Tecovirimat weakly induces CYP3A4, increasing palbociclib clearance.
What to do
No dose change is usually needed for the short tecovirimat course. Monitor for reduced palbociclib effect if prolonged use is necessary.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Palbociclib
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Palbociclib with Tecovirimat?
MediHelp rates the interaction as minor. Palbociclib and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and might slightly lower palbociclib exposure. The clinical effect is likely small and tecovirimat is used for short courses.
How serious is the interaction between Palbociclib and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed for the short tecovirimat course. Monitor for reduced palbociclib effect if prolonged use is necessary.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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