Drug interactions
Palbociclib + Trastuzumab deruxtecan
Severity: Moderate
Palbociclib and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause neutropenia and interstitial lung disease. Combined use may increase the risk of febrile neutropenia and infection.
What this interaction means in plain words
Palbociclib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palbociclib belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression; no pharmacokinetic interaction is established.
What to do
Monitor complete blood counts before each cycle and watch for fever or infection. Hold or reduce doses according to labeling for neutropenia, and monitor for respiratory symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Palbociclib with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Palbociclib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause neutropenia and interstitial lung disease. Combined use may increase the risk of febrile neutropenia and infection.
How serious is the interaction between Palbociclib and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts before each cycle and watch for fever or infection. Hold or reduce doses according to labeling for neutropenia, and monitor for respiratory symptoms.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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