Drug interactions
Palbociclib + Voriconazole
Severity: Major
Palbociclib and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases palbociclib exposure, which may worsen neutropenia and other adverse effects.
What this interaction means in plain words
Palbociclib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Palbociclib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole strongly inhibits CYP3A4, the main metabolic pathway of palbociclib.
What to do
Avoid a strong CYP3A inhibitor if possible; otherwise reduce the palbociclib dose as per labeling and monitor blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Palbociclib with Voriconazole?
MediHelp rates the interaction as major. Palbociclib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole increases palbociclib exposure, which may worsen neutropenia and other adverse effects.
How serious is the interaction between Palbociclib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a strong CYP3A inhibitor if possible; otherwise reduce the palbociclib dose as per labeling and monitor blood counts.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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