Drug interactions
Paliperidone + Stiripentol
Severity: Moderate
Paliperidone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits P-glycoprotein and may increase paliperidone exposure, and it is itself sedating. Together this may increase drowsiness and other dose-related adverse effects of paliperidone.
What this interaction means in plain words
Paliperidone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
P-gp inhibition by stiripentol raises paliperidone levels, with additive CNS depression.
What to do
Monitor for sedation, extrapyramidal symptoms and QTc effects, and reduce the paliperidone dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Paliperidone with Stiripentol?
MediHelp rates the interaction as moderate. Paliperidone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits P-glycoprotein and may increase paliperidone exposure, and it is itself sedating. Together this may increase drowsiness and other dose-related adverse effects of paliperidone.
How serious is the interaction between Paliperidone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal symptoms and QTc effects, and reduce the paliperidone dose if adverse effects develop.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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