Drug interactions
Paliperidone + Trazodone
Severity: Moderate
Paliperidone and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and cause sedation and orthostatic hypotension. Together they raise the risk of arrhythmia, particularly with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Paliperidone and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and additive CNS depressant and alpha-1 blocking effects.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium. Monitor for sedation, dizziness and syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Paliperidone with Trazodone?
MediHelp rates the interaction as moderate. Paliperidone and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval and cause sedation and orthostatic hypotension. Together they raise the risk of arrhythmia, particularly with electrolyte disturbance or cardiac disease.
How serious is the interaction between Paliperidone and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium. Monitor for sedation, dizziness and syncope.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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