Drug interactions
Paliperidone + Triclabendazole
Severity: Moderate
Paliperidone and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combined use may increase the risk of ventricular arrhythmia including torsades de pointes. The risk is greater with bradycardia, electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Paliperidone and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check baseline ECG and electrolytes and correct potassium and magnesium abnormalities. Monitor QTc during the short triclabendazole course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Triclabendazole
Frequently asked questions
Can I take Paliperidone with Triclabendazole?
MediHelp rates the interaction as moderate. Paliperidone and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combined use may increase the risk of ventricular arrhythmia including torsades de pointes. The risk is greater with bradycardia, electrolyte disturbances or cardiac disease.
How serious is the interaction between Paliperidone and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and correct potassium and magnesium abnormalities. Monitor QTc during the short triclabendazole course.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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