Drug interactions
Pancuronium + Prochlorperazine
Severity: Minor
Pancuronium and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
There is no well-established clinically significant interaction between prochlorperazine and this neuromuscular blocker. Phenothiazines have been reported to modestly potentiate neuromuscular blockade in some settings, but the effect is not consistent.
What this interaction means in plain words
Pancuronium and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pancuronium belongs to Musculoskeletal; Prochlorperazine belongs to Central Nervous System.
Why it happens
Possible weak additive effects at the neuromuscular junction or autonomic sites; the mechanism is not firmly established.
What to do
Monitor neuromuscular function with a peripheral nerve stimulator during anesthesia and titrate the blocker to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Pancuronium
Frequently asked questions
Can I take Pancuronium with Prochlorperazine?
MediHelp rates the interaction as minor. Pancuronium and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. There is no well-established clinically significant interaction between prochlorperazine and this neuromuscular blocker. Phenothiazines have been reported to modestly potentiate neuromuscular blockade in some settings, but the effect is not consistent.
How serious is the interaction between Pancuronium and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a peripheral nerve stimulator during anesthesia and titrate the blocker to effect.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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