Drug interactions
Calcium carbonate + Vismodegib
Severity: Minor
Calcium carbonate and Vismodegib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vismodegib solubility depends on pH, so agents that raise gastric pH may reduce its absorption. The effect of this on antitumor efficacy is unknown.
What this interaction means in plain words
Calcium carbonate and Vismodegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium carbonate belongs to Gastrointestinal Tract; Vismodegib belongs to Oncology.
Why it happens
Raised gastric pH from antacid reduces vismodegib solubility and absorption.
What to do
Separate calcium carbonate from vismodegib by a couple of hours and monitor tumor response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium carbonate
Other interactions of Vismodegib
- Dexlansoprazole + Vismodegib Moderate
- Esomeprazole + Vismodegib Moderate
- Famotidine + Vismodegib Moderate
- Omeprazole + Vismodegib Moderate
- Pantoprazole + Vismodegib Moderate
- Aluminum hydroxide + Vismodegib Minor
Frequently asked questions
Can I take Calcium carbonate with Vismodegib?
MediHelp rates the interaction as minor. Calcium carbonate and Vismodegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vismodegib solubility depends on pH, so agents that raise gastric pH may reduce its absorption. The effect of this on antitumor efficacy is unknown.
How serious is the interaction between Calcium carbonate and Vismodegib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate calcium carbonate from vismodegib by a couple of hours and monitor tumor response.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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