Drug interactions
Papaverine + Sevoflurane
Severity: Minor
Papaverine and Sevoflurane: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaverine is a smooth muscle relaxant and vasodilator and, particularly when given intravenously, may add to sevoflurane's hypotensive effects. The legacy sedation concept is not a well established effect of papaverine.
What this interaction means in plain words
Papaverine and Sevoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Papaverine belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Possible additive vasodilation and hypotension; a clinically meaningful sedative interaction is not established.
What to do
Monitor blood pressure when papaverine is injected during sevoflurane anesthesia and treat hypotension as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sevoflurane
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Papaverine with Sevoflurane?
MediHelp rates the interaction as minor. Papaverine and Sevoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Papaverine is a smooth muscle relaxant and vasodilator and, particularly when given intravenously, may add to sevoflurane's hypotensive effects. The legacy sedation concept is not a well established effect of papaverine.
How serious is the interaction between Papaverine and Sevoflurane?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when papaverine is injected during sevoflurane anesthesia and treat hypotension as needed.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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