Drug interactions
Paromomycin + Piroxicam
Severity: Minor
Paromomycin and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides, but oral paromomycin is minimally absorbed, so systemic accumulation is unlikely in most patients. Concern is limited to situations with significant absorption or renal impairment.
What this interaction means in plain words
Paromomycin and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paromomycin belongs to Anti Bacterial; Piroxicam belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal blood flow and glomerular filtration may reduce clearance of any absorbed aminoglycoside.
What to do
No routine action is needed; check renal function if the patient has kidney disease or bowel inflammation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Paromomycin with Piroxicam?
MediHelp rates the interaction as minor. Paromomycin and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can reduce renal clearance of aminoglycosides, but oral paromomycin is minimally absorbed, so systemic accumulation is unlikely in most patients. Concern is limited to situations with significant absorption or renal impairment.
How serious is the interaction between Paromomycin and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check renal function if the patient has kidney disease or bowel inflammation.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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