Drug interactions
Paromomycin + Succinylcholine
Severity: Moderate
Paromomycin and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paromomycin is an aminoglycoside that is minimally absorbed orally, but absorption may increase with damaged intestinal mucosa or renal failure. Absorbed aminoglycosides can potentiate neuromuscular blockers, prolonging paralysis and apnea.
What this interaction means in plain words
Paromomycin and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paromomycin belongs to Anti Bacterial; Succinylcholine belongs to Musculoskeletal.
Why it happens
Aminoglycosides reduce presynaptic acetylcholine release and postsynaptic sensitivity, adding to neuromuscular blockade.
What to do
Inform the anesthesia team about paromomycin use, especially with renal impairment or bowel disease. Monitor neuromuscular function and ensure ventilatory support for delayed recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Succinylcholine
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Paromomycin with Succinylcholine?
MediHelp rates the interaction as moderate. Paromomycin and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paromomycin is an aminoglycoside that is minimally absorbed orally, but absorption may increase with damaged intestinal mucosa or renal failure. Absorbed aminoglycosides can potentiate neuromuscular blockers, prolonging paralysis and apnea.
How serious is the interaction between Paromomycin and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team about paromomycin use, especially with renal impairment or bowel disease. Monitor neuromuscular function and ensure ventilatory support for delayed recovery.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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