Drug interactions
Paromomycin + Tacrolimus
Severity: Minor
Paromomycin and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is poorly absorbed but absorption can increase with damaged gut mucosa or renal impairment. In that setting additive nephrotoxicity and ototoxicity with tacrolimus is possible.
What this interaction means in plain words
Paromomycin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paromomycin belongs to Anti Bacterial; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive nephrotoxic potential from systemically absorbed aminoglycoside and calcineurin inhibitor.
What to do
Monitor renal function in patients with renal impairment or intestinal disease receiving both drugs, and stop paromomycin if renal function worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Paromomycin and Tacrolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Paromomycin with Tacrolimus?
MediHelp rates the interaction as minor. Paromomycin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin is poorly absorbed but absorption can increase with damaged gut mucosa or renal impairment. In that setting additive nephrotoxicity and ototoxicity with tacrolimus is possible.
How serious is the interaction between Paromomycin and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function in patients with renal impairment or intestinal disease receiving both drugs, and stop paromomycin if renal function worsens.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
