Drug interactions
Paroxetine + Rolapitant
Severity: Minor
Paroxetine and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine is a CYP2D6 substrate and itself a strong CYP2D6 inhibitor, so the additional inhibition from rolapitant may have limited effect. Paroxetine exposure could still rise, with more nausea, sedation or serotonergic effects.
What this interaction means in plain words
Paroxetine and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paroxetine belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, which may slightly reduce paroxetine metabolism.
What to do
No routine dose change is needed. Monitor for paroxetine adverse effects and reduce the dose if they emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Rolapitant?
MediHelp rates the interaction as minor. Paroxetine and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paroxetine is a CYP2D6 substrate and itself a strong CYP2D6 inhibitor, so the additional inhibition from rolapitant may have limited effect. Paroxetine exposure could still rise, with more nausea, sedation or serotonergic effects.
How serious is the interaction between Paroxetine and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for paroxetine adverse effects and reduce the dose if they emerge.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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