Drug interactions
Pegvisomant + Pentazocine
Severity: Moderate
Pegvisomant and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids may be associated with lower measured IGF-1 or altered growth hormone axis activity, and labeling for pegvisomant notes that patients on opioids may need higher pegvisomant doses. The clinical effect is variable and not well characterized for pentazocine specifically.
What this interaction means in plain words
Pegvisomant and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pegvisomant belongs to Endocrine; Pentazocine belongs to Musculoskeletal.
Why it happens
The mechanism is not established.
What to do
Monitor serum IGF-I when starting or stopping pentazocine and adjust the pegvisomant dose as indicated by response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Pegvisomant with Pentazocine?
MediHelp rates the interaction as moderate. Pegvisomant and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids may be associated with lower measured IGF-1 or altered growth hormone axis activity, and labeling for pegvisomant notes that patients on opioids may need higher pegvisomant doses. The clinical effect is variable and not well characterized for pentazocine specifically.
How serious is the interaction between Pegvisomant and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum IGF-I when starting or stopping pentazocine and adjust the pegvisomant dose as indicated by response.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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