Drug interactions
Pegvisomant + Saxagliptin
Severity: Minor
Pegvisomant and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant blocks growth hormone action and lowers IGF-1, which can improve insulin sensitivity and reduce glucose in acromegaly. This may add to saxagliptin's effect, mostly relevant if other antidiabetic drugs are used.
What this interaction means in plain words
Pegvisomant and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pegvisomant belongs to Endocrine; Saxagliptin belongs to Endocrine.
Why it happens
Growth hormone receptor antagonism improves insulin sensitivity, additive to DPP-4 inhibition.
What to do
Monitor blood glucose after starting pegvisomant and reduce doses of insulin or sulfonylureas if hypoglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Pegvisomant with Saxagliptin?
MediHelp rates the interaction as minor. Pegvisomant and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pegvisomant blocks growth hormone action and lowers IGF-1, which can improve insulin sensitivity and reduce glucose in acromegaly. This may add to saxagliptin's effect, mostly relevant if other antidiabetic drugs are used.
How serious is the interaction between Pegvisomant and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting pegvisomant and reduce doses of insulin or sulfonylureas if hypoglycemia develops.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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