Drug interactions
Pegvisomant + Tapentadol
Severity: Minor
Pegvisomant and Tapentadol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids have been reported to raise the pegvisomant dose needed for acromegaly control in some patients, but the evidence is limited. Tapentadol has no well-defined effect on pegvisomant, and the mechanism is not established.
What this interaction means in plain words
Pegvisomant and Tapentadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pegvisomant belongs to Endocrine; Tapentadol belongs to Musculoskeletal.
Why it happens
Mechanism not established.
What to do
Monitor IGF-I levels if tapentadol is started or stopped in a patient on pegvisomant, and adjust the pegvisomant dose according to the response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Pegvisomant with Tapentadol?
MediHelp rates the interaction as minor. Pegvisomant and Tapentadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids have been reported to raise the pegvisomant dose needed for acromegaly control in some patients, but the evidence is limited. Tapentadol has no well-defined effect on pegvisomant, and the mechanism is not established.
How serious is the interaction between Pegvisomant and Tapentadol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor IGF-I levels if tapentadol is started or stopped in a patient on pegvisomant, and adjust the pegvisomant dose according to the response.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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