Drug interactions
Pemigatinib + Posaconazole
Severity: Major
Pemigatinib and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pemigatinib is cleared mainly by CYP3A4, so posaconazole can substantially increase its exposure. This raises the risk of adverse effects such as hyperphosphatemia, ocular toxicity and stomatitis.
What this interaction means in plain words
Pemigatinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pemigatinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of pemigatinib.
What to do
Use an alternative antifungal if possible. If unavoidable, reduce the pemigatinib dose as per labeling and monitor for toxicity, resuming the prior dose after the inhibitor has been stopped for about three half-lives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Pemigatinib
Frequently asked questions
Can I take Pemigatinib with Posaconazole?
MediHelp rates the interaction as major. Pemigatinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pemigatinib is cleared mainly by CYP3A4, so posaconazole can substantially increase its exposure. This raises the risk of adverse effects such as hyperphosphatemia, ocular toxicity and stomatitis.
How serious is the interaction between Pemigatinib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antifungal if possible. If unavoidable, reduce the pemigatinib dose as per labeling and monitor for toxicity, resuming the prior dose after the inhibitor has been stopped for about three half-lives.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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