Drug interactions
Pentazocine + Stiripentol
Severity: Moderate
Pentazocine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol commonly causes drowsiness, and combining it with an opioid can increase sedation and impair alertness. Stiripentol also inhibits several CYP enzymes, which could modestly alter opioid exposure.
What this interaction means in plain words
Pentazocine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pentazocine belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Additive central nervous system depression, with possible CYP inhibition by stiripentol.
What to do
Monitor for excessive sedation and respiratory depression, particularly during dose changes. Counsel against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Pentazocine with Stiripentol?
MediHelp rates the interaction as moderate. Pentazocine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol commonly causes drowsiness, and combining it with an opioid can increase sedation and impair alertness. Stiripentol also inhibits several CYP enzymes, which could modestly alter opioid exposure.
How serious is the interaction between Pentazocine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, particularly during dose changes. Counsel against driving and alcohol.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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