Drug interactions
Pentazocine + Trazodone
Severity: Moderate
Pentazocine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination can increase drowsiness and orthostatic hypotension. Because both have serotonergic activity, serotonin syndrome is a possible but uncommon risk.
What this interaction means in plain words
Pentazocine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pentazocine belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression, hypotension and possible additive serotonergic effects.
What to do
Use the lowest effective doses and monitor sedation and blood pressure. Watch for agitation, tremor, hyperthermia or clonus and stop treatment if serotonin toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Pentazocine with Trazodone?
MediHelp rates the interaction as moderate. Pentazocine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination can increase drowsiness and orthostatic hypotension. Because both have serotonergic activity, serotonin syndrome is a possible but uncommon risk.
How serious is the interaction between Pentazocine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and blood pressure. Watch for agitation, tremor, hyperthermia or clonus and stop treatment if serotonin toxicity develops.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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