Drug interactions
Perampanel + Valproic acid
Severity: Minor
Perampanel and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valproate has a minor effect on perampanel clearance, and perampanel does not meaningfully raise valproate levels. Perampanel is a weak CYP3A4 inducer rather than an inhibitor at usual doses. Clinically important changes are not expected, although additive CNS adverse effects can occur.
What this interaction means in plain words
Perampanel and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Perampanel belongs to Central Nervous System; Valproic acid belongs to Central Nervous System.
Why it happens
No significant pharmacokinetic mechanism is established; there may be a small change in valproate clearance, and the pharmacodynamic CNS effects are additive.
What to do
No dose adjustment is needed. Monitor for dizziness, somnolence and mood or behavioral changes during perampanel titration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Perampanel with Valproic acid?
MediHelp rates the interaction as minor. Perampanel and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valproate has a minor effect on perampanel clearance, and perampanel does not meaningfully raise valproate levels. Perampanel is a weak CYP3A4 inducer rather than an inhibitor at usual doses. Clinically important changes are not expected, although additive CNS adverse effects can occur.
How serious is the interaction between Perampanel and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for dizziness, somnolence and mood or behavioral changes during perampanel titration.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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