Drug interactions
Perphenazine + Propylhexedrine
Severity: Minor
Perphenazine and Propylhexedrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is a sympathomimetic nasal decongestant with low systemic exposure at normal inhalation doses. A clinically meaningful interaction with perphenazine is unlikely, though misuse or high exposure could affect heart rate and blood pressure.
What this interaction means in plain words
Perphenazine and Propylhexedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Perphenazine belongs to Central Nervous System; Propylhexedrine belongs to Respiratory.
Why it happens
Opposing adrenergic and CNS effects; no well-established mechanism.
What to do
No action needed at labeled doses. Advise against use beyond recommended amounts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Perphenazine with Propylhexedrine?
MediHelp rates the interaction as minor. Perphenazine and Propylhexedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propylhexedrine is a sympathomimetic nasal decongestant with low systemic exposure at normal inhalation doses. A clinically meaningful interaction with perphenazine is unlikely, though misuse or high exposure could affect heart rate and blood pressure.
How serious is the interaction between Perphenazine and Propylhexedrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action needed at labeled doses. Advise against use beyond recommended amounts.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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