Drug interactions
Perphenazine + Sevoflurane
Severity: Moderate
Perphenazine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine may augment the sedative and hypotensive effects of sevoflurane. Both agents can prolong the QT interval, adding to arrhythmia risk during anesthesia.
What this interaction means in plain words
Perphenazine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression and QT prolongation.
What to do
Inform the anesthesia team of perphenazine use and review the baseline ECG. Monitor QTc, blood pressure and electrolytes perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Perphenazine with Sevoflurane?
MediHelp rates the interaction as moderate. Perphenazine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine may augment the sedative and hypotensive effects of sevoflurane. Both agents can prolong the QT interval, adding to arrhythmia risk during anesthesia.
How serious is the interaction between Perphenazine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of perphenazine use and review the baseline ECG. Monitor QTc, blood pressure and electrolytes perioperatively.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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