Drug interactions
Perphenazine + Tiotropium-olodaterol
Severity: Moderate
Perphenazine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has anticholinergic activity that adds to tiotropium, which may increase dry mouth, urinary retention, constipation and, rarely, raise intraocular pressure. Perphenazine can also prolong the QT interval, and olodaterol may add to arrhythmia risk through hypokalemia and sympathetic stimulation.
What this interaction means in plain words
Perphenazine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects plus additive QT prolongation and beta2-mediated cardiac effects.
What to do
Monitor for anticholinergic adverse effects such as urinary retention and narrow-angle glaucoma symptoms. Check ECG and potassium in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Perphenazine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine has anticholinergic activity that adds to tiotropium, which may increase dry mouth, urinary retention, constipation and, rarely, raise intraocular pressure. Perphenazine can also prolong the QT interval, and olodaterol may add to arrhythmia risk through hypokalemia and sympathetic stimulation.
How serious is the interaction between Perphenazine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects such as urinary retention and narrow-angle glaucoma symptoms. Check ECG and potassium in patients with cardiac risk factors.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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