Drug interactions
Pexidartinib + Ticlopidine
Severity: Major
Pexidartinib and Ticlopidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause liver injury, and pexidartinib carries a boxed warning for serious and potentially fatal hepatotoxicity. Combining them may increase the risk of liver damage. Ticlopidine also causes cholestatic hepatitis in some patients.
What this interaction means in plain words
Pexidartinib and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pexidartinib belongs to Oncology; Ticlopidine belongs to Cardiovascular.
Why it happens
Additive hepatotoxicity from two drugs that can each injure the liver.
What to do
Avoid concurrent use and choose a non-hepatotoxic antiplatelet agent. If unavoidable, monitor liver enzymes and bilirubin frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ticlopidine
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Ticlopidine?
MediHelp rates the interaction as major. Pexidartinib and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause liver injury, and pexidartinib carries a boxed warning for serious and potentially fatal hepatotoxicity. Combining them may increase the risk of liver damage. Ticlopidine also causes cholestatic hepatitis in some patients.
How serious is the interaction between Pexidartinib and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-hepatotoxic antiplatelet agent. If unavoidable, monitor liver enzymes and bilirubin frequently.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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