Drug interactions
Pilocarpine + Umeclidinium
Severity: Moderate
Pilocarpine and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist and umeclidinium is a muscarinic antagonist, so they can counteract each other. Pilocarpine's effects on salivation, sweating or the eye may be blunted, though systemic exposure to inhaled umeclidinium is low.
What this interaction means in plain words
Pilocarpine and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pilocarpine belongs to Miscellaneous; Umeclidinium belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced pilocarpine response, such as persistent dry mouth, and adjust pilocarpine dosing if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Pilocarpine with Umeclidinium?
MediHelp rates the interaction as moderate. Pilocarpine and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a muscarinic agonist and umeclidinium is a muscarinic antagonist, so they can counteract each other. Pilocarpine's effects on salivation, sweating or the eye may be blunted, though systemic exposure to inhaled umeclidinium is low.
How serious is the interaction between Pilocarpine and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced pilocarpine response, such as persistent dry mouth, and adjust pilocarpine dosing if needed.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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