Drug interactions
Piroxicam + Sotalol
Severity: Moderate
Piroxicam and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam may reduce the antihypertensive effect of sotalol, particularly with continued use. NSAIDs may also cause fluid retention and renal impairment, which can raise sotalol exposure and the risk of QT-related effects.
What this interaction means in plain words
Piroxicam and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Piroxicam belongs to Musculoskeletal; Sotalol belongs to Cardiovascular.
Why it happens
NSAID prostaglandin inhibition causes sodium retention and vasoconstriction, and reduced renal function can lessen sotalol elimination.
What to do
Monitor blood pressure, heart rate and renal function when used together, and adjust sotalol if needed. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Piroxicam with Sotalol?
MediHelp rates the interaction as moderate. Piroxicam and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam may reduce the antihypertensive effect of sotalol, particularly with continued use. NSAIDs may also cause fluid retention and renal impairment, which can raise sotalol exposure and the risk of QT-related effects.
How serious is the interaction between Piroxicam and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and renal function when used together, and adjust sotalol if needed. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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