Drug interactions
Piroxicam + Vortioxetine
Severity: Moderate
Piroxicam and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine, like other serotonergic antidepressants, impairs platelet serotonin uptake and can increase bleeding tendency. Combined with piroxicam, which inhibits platelet function and irritates the gastric mucosa, the risk of gastrointestinal and other bleeding is increased.
What this interaction means in plain words
Piroxicam and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Piroxicam belongs to Musculoskeletal; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive impairment of platelet aggregation (SSRI-type serotonin depletion plus NSAID COX-1 inhibition) with NSAID mucosal injury.
What to do
Monitor for signs of GI bleeding and bruising, and consider gastroprotection with a proton pump inhibitor in higher-risk patients. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Piroxicam and Vortioxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Piroxicam with Vortioxetine?
MediHelp rates the interaction as moderate. Piroxicam and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine, like other serotonergic antidepressants, impairs platelet serotonin uptake and can increase bleeding tendency. Combined with piroxicam, which inhibits platelet function and irritates the gastric mucosa, the risk of gastrointestinal and other bleeding is increased.
How serious is the interaction between Piroxicam and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and bruising, and consider gastroprotection with a proton pump inhibitor in higher-risk patients. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
