Drug interactions
Polatuzumab vedotin + Ribociclib
Severity: Moderate
Polatuzumab vedotin and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cytotoxic payload of polatuzumab vedotin, MMAE, is cleared mainly by CYP3A4. Ribociclib may raise MMAE exposure and increase toxicities such as neutropenia and peripheral neuropathy, and both drugs also cause myelosuppression.
What this interaction means in plain words
Polatuzumab vedotin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Polatuzumab vedotin belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing MMAE metabolism, with additive myelosuppression.
What to do
Monitor blood counts and signs of neuropathy and infection closely; delay or reduce treatment per labeling if severe neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Polatuzumab vedotin and Ribociclib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Polatuzumab vedotin
Frequently asked questions
Can I take Polatuzumab vedotin with Ribociclib?
MediHelp rates the interaction as moderate. Polatuzumab vedotin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload of polatuzumab vedotin, MMAE, is cleared mainly by CYP3A4. Ribociclib may raise MMAE exposure and increase toxicities such as neutropenia and peripheral neuropathy, and both drugs also cause myelosuppression.
How serious is the interaction between Polatuzumab vedotin and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of neuropathy and infection closely; delay or reduce treatment per labeling if severe neutropenia occurs.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
