Drug interactions
Polatuzumab vedotin + Voriconazole
Severity: Moderate
Polatuzumab vedotin and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inhibitors can increase unconjugated MMAE exposure from polatuzumab vedotin. This may increase toxicities such as neutropenia and peripheral neuropathy.
What this interaction means in plain words
Polatuzumab vedotin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Polatuzumab vedotin belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of MMAE.
What to do
Monitor closely for neutropenia and neuropathy. Prefer a non-CYP3A-inhibiting antifungal when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Polatuzumab vedotin and Voriconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Polatuzumab vedotin
Frequently asked questions
Can I take Polatuzumab vedotin with Voriconazole?
MediHelp rates the interaction as moderate. Polatuzumab vedotin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 inhibitors can increase unconjugated MMAE exposure from polatuzumab vedotin. This may increase toxicities such as neutropenia and peripheral neuropathy.
How serious is the interaction between Polatuzumab vedotin and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia and neuropathy. Prefer a non-CYP3A-inhibiting antifungal when possible.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
