Drug interactions
Pomalidomide + Ranolazine
Severity: Minor
Pomalidomide and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-glycoprotein and could raise pomalidomide exposure, since pomalidomide is a P-gp substrate. The clinical impact is expected to be small and has not been well characterized.
What this interaction means in plain words
Pomalidomide and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pomalidomide belongs to Miscellaneous; Ranolazine belongs to Cardiovascular.
Why it happens
Possible P-glycoprotein inhibition by ranolazine reducing pomalidomide efflux.
What to do
No dose change is usually needed; monitor for pomalidomide adverse effects such as neutropenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Pomalidomide with Ranolazine?
MediHelp rates the interaction as minor. Pomalidomide and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine inhibits P-glycoprotein and could raise pomalidomide exposure, since pomalidomide is a P-gp substrate. The clinical impact is expected to be small and has not been well characterized.
How serious is the interaction between Pomalidomide and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for pomalidomide adverse effects such as neutropenia.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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