Drug interactions
Porfimer + Promethazine
Severity: Moderate
Porfimer and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Porfimer is a photosensitizer used in photodynamic therapy, and promethazine is a phenothiazine known to cause photosensitivity. Using them together may increase the risk of skin phototoxic reactions after exposure to light.
What this interaction means in plain words
Porfimer and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Porfimer belongs to Miscellaneous; Promethazine belongs to Respiratory.
Why it happens
Additive photosensitizing effects.
What to do
Reinforce strict light-protection precautions during the post-porfimer photosensitivity period. Avoid promethazine during this time if alternatives are available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Porfimer
Frequently asked questions
Can I take Porfimer with Promethazine?
MediHelp rates the interaction as moderate. Porfimer and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Porfimer is a photosensitizer used in photodynamic therapy, and promethazine is a phenothiazine known to cause photosensitivity. Using them together may increase the risk of skin phototoxic reactions after exposure to light.
How serious is the interaction between Porfimer and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reinforce strict light-protection precautions during the post-porfimer photosensitivity period. Avoid promethazine during this time if alternatives are available.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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