Drug interactions
Posaconazole + Prednisone
Severity: Moderate
Posaconazole and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and may increase exposure to prednisolone, enhancing systemic corticosteroid effects. The effect is usually modest for prednisone, but adrenal suppression and Cushingoid effects can be more pronounced with prolonged use.
What this interaction means in plain words
Posaconazole and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Prednisone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of prednisolone by posaconazole.
What to do
Monitor for corticosteroid adverse effects such as hyperglycemia, edema and mood changes, and consider reducing the prednisone dose during prolonged co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Prednisone?
MediHelp rates the interaction as moderate. Posaconazole and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole is a strong CYP3A4 inhibitor and may increase exposure to prednisolone, enhancing systemic corticosteroid effects. The effect is usually modest for prednisone, but adrenal suppression and Cushingoid effects can be more pronounced with prolonged use.
How serious is the interaction between Posaconazole and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as hyperglycemia, edema and mood changes, and consider reducing the prednisone dose during prolonged co-therapy.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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