Drug interactions
Posaconazole + Quinidine
Severity: Contraindicated
Posaconazole and Quinidine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can raise quinidine concentrations and both agents prolong the QT interval. The result is a substantial risk of torsades de pointes and other serious ventricular arrhythmias. Labeling contraindicates the combination.
What this interaction means in plain words
Posaconazole and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Posaconazole belongs to Anti Fungals; Quinidine belongs to Anti Parasitic.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of quinidine, and both drugs have additive QT-prolonging effects.
What to do
Avoid the combination and select an alternative antifungal or antiarrhythmic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Posaconazole with Quinidine?
MediHelp rates the interaction as contraindicated. Posaconazole and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole can raise quinidine concentrations and both agents prolong the QT interval. The result is a substantial risk of torsades de pointes and other serious ventricular arrhythmias. Labeling contraindicates the combination.
How serious is the interaction between Posaconazole and Quinidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select an alternative antifungal or antiarrhythmic.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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