Drug interactions
Posaconazole + Ramelteon
Severity: Minor
Posaconazole and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase ramelteon exposure, although ramelteon is primarily metabolised by CYP1A2, with CYP3A4 playing a minor role. Increased sedation or dizziness may occur.
What this interaction means in plain words
Posaconazole and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Posaconazole belongs to Anti Fungals; Ramelteon belongs to Central Nervous System.
Why it happens
Inhibition of the minor CYP3A4 pathway of ramelteon metabolism.
What to do
No dose adjustment is normally needed; advise patients to report excessive daytime sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Posaconazole with Ramelteon?
MediHelp rates the interaction as minor. Posaconazole and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may increase ramelteon exposure, although ramelteon is primarily metabolised by CYP1A2, with CYP3A4 playing a minor role. Increased sedation or dizziness may occur.
How serious is the interaction between Posaconazole and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is normally needed; advise patients to report excessive daytime sedation.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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