Drug interactions
Posaconazole + Regorafenib
Severity: Major
Posaconazole and Regorafenib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole increases regorafenib exposure and reduces formation of its active metabolites M-2 and M-5, so the net clinical effect is unpredictable. Regorafenib labeling advises avoiding strong CYP3A4 inhibitors because of possible toxicity, including hepatotoxicity.
What this interaction means in plain words
Posaconazole and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Posaconazole belongs to Anti Fungals; Regorafenib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated regorafenib metabolism.
What to do
Avoid concomitant use and select an antifungal with weaker CYP3A4 inhibition. If it is unavoidable, monitor liver function and tolerability closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Regorafenib
Frequently asked questions
Can I take Posaconazole with Regorafenib?
MediHelp rates the interaction as major. Posaconazole and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole increases regorafenib exposure and reduces formation of its active metabolites M-2 and M-5, so the net clinical effect is unpredictable. Regorafenib labeling advises avoiding strong CYP3A4 inhibitors because of possible toxicity, including hepatotoxicity.
How serious is the interaction between Posaconazole and Regorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select an antifungal with weaker CYP3A4 inhibition. If it is unavoidable, monitor liver function and tolerability closely.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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