Drug interactions
Posaconazole + Sarecycline
Severity: Minor
Posaconazole and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is predicted to have little clinically meaningful effect on posaconazole. Any change in posaconazole exposure through efflux transporters is likely small.
What this interaction means in plain words
Posaconazole and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Posaconazole belongs to Anti Fungals; Sarecycline belongs to Anti Bacterial.
Why it happens
Sarecycline has weak in vitro effects on P-glycoprotein, and the mechanism for a clinical interaction is not well established.
What to do
No routine action is needed; monitor for posaconazole adverse effects if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Posaconazole with Sarecycline?
MediHelp rates the interaction as minor. Posaconazole and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is predicted to have little clinically meaningful effect on posaconazole. Any change in posaconazole exposure through efflux transporters is likely small.
How serious is the interaction between Posaconazole and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor for posaconazole adverse effects if symptoms arise.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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