Drug interactions
Posaconazole + Saxagliptin-metformin
Severity: Moderate
Posaconazole and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and increases saxagliptin exposure by slowing its metabolism. Higher saxagliptin levels may increase the risk of adverse effects.
What this interaction means in plain words
Posaconazole and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4/5-mediated saxagliptin metabolism.
What to do
Limit saxagliptin to 2.5 mg daily during posaconazole therapy; with the fixed-dose combination, switch to separate components to allow this dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Posaconazole and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole is a strong CYP3A4 inhibitor and increases saxagliptin exposure by slowing its metabolism. Higher saxagliptin levels may increase the risk of adverse effects.
How serious is the interaction between Posaconazole and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg daily during posaconazole therapy; with the fixed-dose combination, switch to separate components to allow this dose.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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