Drug interactions
Posaconazole + Secobarbital
Severity: Moderate
Posaconazole and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce drug-metabolising enzymes and may lower posaconazole exposure, which could lead to antifungal failure. The effect is expected to develop with repeated barbiturate dosing.
What this interaction means in plain words
Posaconazole and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of UDP-glucuronidation and efflux transporters (and possibly CYP3A4) by barbiturates increases posaconazole clearance.
What to do
Avoid the combination if possible; otherwise monitor posaconazole trough concentrations and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Posaconazole with Secobarbital?
MediHelp rates the interaction as moderate. Posaconazole and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce drug-metabolising enzymes and may lower posaconazole exposure, which could lead to antifungal failure. The effect is expected to develop with repeated barbiturate dosing.
How serious is the interaction between Posaconazole and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor posaconazole trough concentrations and clinical response.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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