Drug interactions
Posaconazole + Ticagrelor
Severity: Major
Posaconazole and Ticagrelor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole markedly raises ticagrelor exposure, which increases the risk of bleeding. Labeling advises against using ticagrelor with strong CYP3A inhibitors.
What this interaction means in plain words
Posaconazole and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Posaconazole belongs to Anti Fungals; Ticagrelor belongs to Cardiovascular.
Why it happens
Strong CYP3A4 inhibition by posaconazole reduces ticagrelor clearance.
What to do
Avoid the combination and choose an alternative antifungal or antiplatelet agent such as prasugrel or clopidogrel where appropriate; monitor for bleeding if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Posaconazole with Ticagrelor?
MediHelp rates the interaction as major. Posaconazole and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole markedly raises ticagrelor exposure, which increases the risk of bleeding. Labeling advises against using ticagrelor with strong CYP3A inhibitors.
How serious is the interaction between Posaconazole and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antifungal or antiplatelet agent such as prasugrel or clopidogrel where appropriate; monitor for bleeding if unavoidable.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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