Drug interactions
Posaconazole + Tolazamide
Severity: Moderate
Posaconazole and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azole antifungals can raise sulfonylurea concentrations and enhance hypoglycemia. The effect for tolazamide with posaconazole is theoretical and less well characterized than for other azoles.
What this interaction means in plain words
Posaconazole and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Tolazamide belongs to Endocrine.
Why it happens
Inhibition of hepatic metabolism of the sulfonylurea by posaconazole; the specific enzyme involvement is not firmly established.
What to do
Monitor blood glucose when starting or stopping posaconazole and lower the tolazamide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Posaconazole with Tolazamide?
MediHelp rates the interaction as moderate. Posaconazole and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azole antifungals can raise sulfonylurea concentrations and enhance hypoglycemia. The effect for tolazamide with posaconazole is theoretical and less well characterized than for other azoles.
How serious is the interaction between Posaconazole and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping posaconazole and lower the tolazamide dose if hypoglycemia develops.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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