Drug interactions
Posaconazole + Umeclidinium-vilanterol
Severity: Major
Posaconazole and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can prolong the QT interval and strongly inhibits CYP3A4, which metabolizes vilanterol. Exposure to vilanterol may rise, increasing adrenergic and cardiac effects on top of the QT effect.
What this interaction means in plain words
Posaconazole and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Posaconazole belongs to Anti Fungals; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
CYP3A4 inhibition raising vilanterol exposure, combined with additive QT prolongation.
What to do
Monitor ECG, heart rate and potassium, and watch for beta-agonist adverse effects such as tremor and palpitations. Consider an alternative antifungal or bronchodilator if cardiac risk is high.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Posaconazole and Umeclidinium-vilanterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Umeclidinium-vilanterol
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Posaconazole with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Posaconazole and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole can prolong the QT interval and strongly inhibits CYP3A4, which metabolizes vilanterol. Exposure to vilanterol may rise, increasing adrenergic and cardiac effects on top of the QT effect.
How serious is the interaction between Posaconazole and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and potassium, and watch for beta-agonist adverse effects such as tremor and palpitations. Consider an alternative antifungal or bronchodilator if cardiac risk is high.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
